I was getting this error while running my biztalk application. After searching on search engine, I have not received any response. Then I tried to see the host instances are working properly or not. And there I found the actual solution. That my application reunning in a host instance(test) was not running. I start that orchestraion and test my application. Its working fine now. Check your Host Instances working properly in which you have configured your BizTalk application. It will resolve your error.